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Gα12 enhances RhoA, Rho kinase, changes expression of some genes, and slows dephosphorylation of myosin light chains affecting smooth muscle tone

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Senolytic therapies, which target and eliminate senescent cells, may need to be administered intermittently, while senomorphics, which modulate the SASP, may be more suitable for continuous or long-term treatment.36 Additionally, in combination therapies, determining the timing and synergy of different agents is complex.258 The effects of senolytic and senomorphic agents may be enhanced or diminished depending on when and how they are administered.35 Therefore, clinical trials will need to explore various combinations and schedules to identify the most effective regimen for targeting senescence and promoting healthy aging without causing harm